TRAP1 antibody (AA 501-650) (Biotin)

Catalog No. ABIN686649

This anti-TRAP1 antibody is a Rabbit Polyclonal antibody detecting TRAP1 in ELISA, IHC (p) and IHC (fro). Suitable for Rat.

Quick Overview for TRAP1 antibody (AA 501-650) (Biotin) (ABIN686649)

Target: TRAP1 (TNF Receptor-Associated Protein 1 (TRAP1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAP1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TRAP1 Antibody (Biotin)

Binding Specificity: AA 501-650

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HSP75

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TRAP1

Target: TRAP1 (TNF Receptor-Associated Protein 1 (TRAP1))

Alternative Name: HSP75/TRAP1

Background:

Synonyms: HSP75, HSP 75, HSP90L, TRAP-1, Heat shock protein 75 kDa, mitochondrial, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP1

Background: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene ID: 10131

UniProt: Q12931