tau antibody (pSer202, pThr205) (APC)

Catalog No. ABIN6932894

Product Details anti-tau Antibody (APC)

Target: tau (tau Protein)

Binding Specificity: pSer202, pThr205

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This tau antibody is conjugated to APC

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Dot Blot (DB)

Specificity: Expressed in neurons.,Detects ~79 kDa.

Cross-Reactivity: Human, Mouse

Purification: Affinity Purified

Immunogen: Synthetic peptide of Human Phospho Tau (Ser202/Thr205)

Clone: AH36

Isotype: IgG

Application Details

Application Notes:

• WB (1:500)
• ICC/IF (1:500)
• IHC (1:500)
• optimal dilutions for assays should be determined by the user.

Comment:

A 1:500 dilution of ABIN6932894 was sufficient for detection of Tau in 10 μg Baculovirus by dot blot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for tau

Target: tau (tau Protein)

Alternative Name: Tau (tau Products)

Background: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3).

Gene ID: 4137

UniProt: P10636