HIV-1 p24 antibody (CF®488A)

Catalog No. ABIN6933792

The Mouse Monoclonal anti-HIV-1 p24 antibody has been validated for IF and ICC. It is suitable to detect HIV-1 p24 in samples from Human Immunodeficiency Virus (HIV).

Quick Overview for HIV-1 p24 antibody (CF®488A) (ABIN6933792)

Target: HIV-1 p24 (Human Immunodeficiency Virus 1 Capsid (HIV-1 p24))

Reactivity: Human Immunodeficiency Virus (HIV)

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIV-1 p24 antibody is conjugated to CF®488A

Application: Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: HIV1-24-661

Product Details anti-HIV-1 p24 Antibody (CF®488A)

Purification: Purified by Protein A/G

Immunogen: Recombinant HIV-1 Gag p24 protein

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: HIV-1 infected cells. Tissues.

Known Application: Immunocytochemistry (Acetone or paraformaldehyde fixed) (1:50-1:100),Immunofluorescence (1:50-1:100),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA and 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for HIV-1 p24

Target: HIV-1 p24 (Human Immunodeficiency Virus 1 Capsid (HIV-1 p24))

Alternative Name: Human Immunodeficiency Virus Type-1 p24 (HIV1-p24)

Target Type: Viral Protein

Background: Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immune deficiency syndrome (AIDS), a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections. HIV mainly infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages and dendritic cells. Two species of HIV infect humans: HIV-1 and HIV-2, with HIV-1 being the more virulent strain. The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins, which are required for virus particle assembly. HIV-1 Gag p24 is a capsid protein that constitutes the core of AIDS virus HIV-1. p6 and p7 are the components of the nucleocapsid, and p17 provides a protective matrix. HIV-1 Gag p24 is indispensable to the reproduction of AIDS virus and constitutes an essential element for the AIDS virus particle construction. As this protein is detectable from the early stage of AIDS virus infection, its measurement is commonly used as an indicator of HIV-1 infection and viral load.

Molecular Weight: 24kDa (mature), 55kDa & 41kDa (precursors)

Gene ID: 155348

UniProt: P04585