Gelsolin antibody

Catalog No. ABIN6937348

The Mouse Monoclonal anti-Gelsolin antibody (Clone CPTC-Gelsolin-1) (ABIN6937348) specifically detects Gelsolin in WB. The antibody is reactive with Human samples.

Quick Overview for Gelsolin antibody (ABIN6937348)

Target: Gelsolin (GSN)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Gelsolin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: CPTC-Gelsolin-1

Product Details anti-Gelsolin Antibody

Specificity: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length protein

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: MCF cell lysate, Tonsil.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Gelsolin

Target: Gelsolin (GSN)

Alternative Name: GSN

Background: Actin depolymerizing factor, ADF, AGEL, Brevin, Gsn,Gelsolin / Actin-depolymerizing Factor
Cellular localisation: Cytoplasm and secreted

Molecular Weight: 90kDa

Gene ID: 2934, 522373

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy