IL-10RA antibody

Catalog No. ABIN6937553

This Rat Monoclonal antibody specifically detects IL-10RA in FACS, IF and Neut. It exhibits reactivity toward Mouse.

Quick Overview for IL-10RA antibody (ABIN6937553)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-10RA antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Neutralization (Neut)

Clone: 1B1-3a

Product Details anti-IL-10RA Antibody

Specificity: This monoclonal antibody recognizes Mouse Interleukin-10 receptor 1 (IL-10R1), a cell surface glycoprotein of approximately 110KDa. Its epitope is localized in the ligand-binding domain in the extracellular region of Mouse IL-10R1. This antibody blocks the binding of IL-10 to its receptor. IL-10R1 is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation.

No Cross-Reactivity: Human

Purification: Purified by Protein A/G

Immunogen: Purified recombinant extracellular region of Mouse IL10RA

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: MPBMC's. Spleen, Thymus, Lymph Node, Placenta, Lung or Liver.

Known Application: Neutralization Studies (Order Ab without Azide),Flow Cytometry (0.5-1 μg/million cells in 0.1ml), Immunofluorescence (0.5-1 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Buffer: 10 mM PBS without BSA and without Azide.

Preservative: Azide free

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.

Expiry Date: 24 months

Target Details for IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Alternative Name: IL-10R1

Molecular Weight: 90-110kDa

Gene ID: 16154

UniProt: Q61727

Pathways: Growth Factor Binding