Recombinant TCL1A antibody (AA 2-109)

Catalog No. ABIN6938519

This Rabbit Monoclonal antibody specifically detects TCL1A in IHC (f). It exhibits reactivity toward Human.

Quick Overview for Recombinant TCL1A antibody (AA 2-109) (ABIN6938519)

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TCL1A antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: TCL1-2747R

Product Details anti-TCL1A Antibody

Binding Specificity: AA 2-109

Specificity: T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human TCL1 protein fragment (around aa 2-109) (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Ramos or Raji cells. Tonsil or T-cell Lymphoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for TCL1A

Target: TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))

Alternative Name: TCL1A

Background: TCL1A, Lymphoma/leukemia, T-cell, Oncogene TCL1, P14 TCL1, T cell leukemia 1, T cell lymphoma 1, T cell lymphoma 1A,T-cell leukemia/lymphoma 1A, TCL1, TCL1A,TCL1 (T-Cell Marker)
Cellular localisation: Nuclear and Cytoplasmic

Molecular Weight: 14kDa

Gene ID: 10232, 2484

UniProt: P56279

Pathways: Stem Cell Maintenance