VLDLR antibody (C-Term)

Catalog No. ABIN6938760

The Mouse Monoclonal anti-VLDLR antibody has been validated for ISt and IHC (f). It is suitable to detect VLDLR in samples from Human.

Quick Overview for VLDLR antibody (C-Term) (ABIN6938760)

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VLDLR antibody is un-conjugated

Application: Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: VLDLR-1337

Product Details anti-VLDLR Antibody

Binding Specificity: C-Term

Specificity: VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Cross-Reactivity (Details): Human. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human VLDLR fragment from c-terminal

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or U-251 cells. Pancreas, Cerebellum, Heart or Skeletal Muscle.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for VLDLR

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Alternative Name: VLDLR

Background: Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR,VLDL-Receptor (Very Low Density Lipoprotein Receptor)
Cellular localisation: Cytoplasmic

Molecular Weight: 143-161kDa

Gene ID: 7436, 370422

UniProt: P98155

Pathways: Cellular Response to Molecule of Bacterial Origin