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S100B antibody

This Rabbit Polyclonal antibody specifically detects S100B in IHC and StM. It exhibits reactivity toward Human, Rat, Mouse and Cow.
Catalog No. ABIN6940561

Quick Overview for S100B antibody (ABIN6940561)

Target

See all S100B Antibodies
S100B (S100 Calcium Binding Protein B (S100B))

Reactivity

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Human, Rat, Mouse, Cow

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This S100B antibody is un-conjugated

Application

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Immunohistochemistry (IHC), Staining Methods (StM)
  • Specificity

    S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.

    Immunogen

    Recombinant full-length human S100B protein

    Isotype

    IgG
  • Application Notes

    Positive Control: Brain, Melanoma or Schwanoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions

    For Research Use only
  • Concentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-80 °C

    Storage Comment

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Expiry Date

    24 months
  • Target

    S100B (S100 Calcium Binding Protein B (S100B))

    Alternative Name

    S100B

    Molecular Weight

    10-12kDa

    Gene ID

    6285

    UniProt

    P04271

    Pathways

    Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins
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