Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) antibody

Catalog No. ABIN6940807

The Mouse Monoclonal anti-Complement 3d (C3d) (Acute Humoral Rejection Marker) antibody (Clone C3D-2891) (ABIN6940807) specifically detects Complement 3d (C3d) (Acute Humoral Rejection Marker) in IHC. The antibody is reactive with Human samples.

Quick Overview for Complement 3d (C3d) (Acute Humoral Rejection Marker) (AA 1250-1450) antibody (ABIN6940807)

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Clone: C3D-2891

Product Details

Binding Specificity: AA 1250-1450

Purpose: Complement 3d (C3d) (Acute Humoral Rejection Marker) Antibody

Specificity: The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1250-1450) of human C3 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes:

Positive Control: Human kidney or rejected renal transplant tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details

Target: Complement 3d (C3d) (Acute Humoral Rejection Marker)

Background:

CPAMD1; Acylation stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment

Human liver cancer or rejected renal transplant tissue.

Molecular Weight: 35kDa (predicted)

Gene ID: 718, 529053

UniProt: P01024