p63 antibody (AA 3-106)

Catalog No. ABIN6940965

This Mouse Monoclonal antibody specifically detects p63 in WB, ELISA and Coat. It exhibits reactivity toward Human.

Quick Overview for p63 antibody (AA 3-106) (ABIN6940965)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This p63 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: TP63-1786

Product Details anti-p63 Antibody

Binding Specificity: AA 3-106

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 3-106) of human p63 protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: HEK293 cells. Prostate Carcinoma or Lung or bladder squamous cell carcinoma.

Known Application: ELISA (For coating, order Ab without BSA),Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: TP63

Background: P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Molecular Weight: 63kDa

Gene ID: 8626

UniProt: Q9H3D4