CD51 antibody

Catalog No. ABIN6941316

This anti-CD51 antibody is a Mouse Monoclonal antibody detecting CD51 in ELISA and Coat. Suitable for Human and Chicken.

Quick Overview for CD51 antibody (ABIN6941316)

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Reactivity: Human, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD51 antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: 23C6

Product Details anti-CD51 Antibody

Specificity: ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin Receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. Reacts with Integrin Alpha V Beta 3. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

No Cross-Reactivity: Cow (Bovine), Pig (Porcine), Rabbit

Purification: Purified by Protein A/G

Immunogen: Osteoclasts from osteoclastomas

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Squamous cells, A375M melanoma cells. A549 cells.

Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD51

Target: CD51 (ITGAV) (Integrin alpha V (ITGAV))

Alternative Name: ITGAV

Molecular Weight: 150-160kDa under non-reducing conditions. Under reducing conditions, it is cleaved into 2 bands of about 125-130kDa +20-25kDa.

Gene ID: 3685

UniProt: P06756

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex