BANF1 antibody

Catalog No. ABIN6942215

This anti-BANF1 antibody is a Rabbit Monoclonal antibody detecting BANF1 in IF (cc), IF (p), IHC (p) and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for BANF1 antibody (ABIN6942215)

Target: BANF1 (Barrier To Autointegration Factor 1 (BANF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BANF1 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 11H3

Product Details anti-BANF1 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Full length recombinant protein of human BANF1.

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for BANF1

Target: BANF1 (Barrier To Autointegration Factor 1 (BANF1))

Alternative Name: BANF1

Background:

Synonyms: Barrier-to-autointegration factor, Breakpoint cluster region protein 1, Barrier-to-autointegration factor N-terminally processed, BANF1, BAF, BCRG1, NGPS, BCRP1,

Background: Barrier-to-autointegration factor (BANF1) binds non-specifically to double stranded DNA, possibly to play a role in tissue- or cell type-specific gene expression by interacting with different homeodomain transcription factors. BANF1 compresses chromatin structure and interacts with the LEM domain of nuclear proteins to play a crucial role in membrane recruitment and chromatin decondensation during nuclear assembly. Additionally, retroviruses like HIV-1 incorporate BANF1 from host cells into preintegration complexes (PICs) to prevent autointegration of retroviral DNA and thereby promote integration of retroviral DNA into the host chromosome.

Gene ID: 8815

UniProt: O75531