ADAP2 antibody (AA 201-300) (HRP)

Catalog No. ABIN6942504

This Rabbit Polyclonal antibody specifically detects ADAP2 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human and Rat.

Quick Overview for ADAP2 antibody (AA 201-300) (HRP) (ABIN6942504)

Target: ADAP2 (ArfGAP with Dual PH Domains 2 (ADAP2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAP2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ADAP2 Antibody (HRP)

Binding Specificity: AA 201-300

Specificity: Possible cross-reactivity with ADAP1 (85 % homology with the immunogen sequence, 43 kDa)

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Centaurin alpha 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADAP2

Target: ADAP2 (ArfGAP with Dual PH Domains 2 (ADAP2))

Alternative Name: Centaurin alpha 2

Background:

Synonyms: ADAP2, ADAP2_HUMAN, Arf-GAP with dual PH domain-containing protein 2, ArfGAP with dual PH domains 2, cent b, Centa 2, CENTA2, Centaurin alpha 2, Centaurin alpha 2 protein, Centaurin beta, Centaurin-alpha-2, Cnt-a2, HSA272195.

Background: The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. This family includes ASAP1, ACAP1, ACAP2, AGAP1, ARAP1, ARAP2, Centaurin a1, Centaurin g3 and the recently discovered Centaurin a2. Expressed in a wide variety of tissues such as fat, heart and skeletal muscle, Centaurin a2 is thought to negatively regulate ARF-mediated actin rearrangement by binding activated PI 3-kinase. Although the exact function of Centaurin a2 is not yet known, its high sequence similarity with Centaurin a1 suggests that it may also act as an ARF6 GTPase.

Gene ID: 55803

UniProt: Q9NPF8