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Complement Factor H antibody

This Rabbit Monoclonal antibody specifically detects Complement Factor H in WB, FACS and IF (cc). It exhibits reactivity toward Human.
Catalog No. ABIN6943395

Quick Overview for Complement Factor H antibody (ABIN6943395)

Target

See all Complement Factor H (CFH) Antibodies
Complement Factor H (CFH)

Reactivity

  • 78
  • 15
  • 14
  • 3
  • 2
Human

Host

  • 63
  • 33
  • 3
  • 2
Rabbit

Clonality

  • 60
  • 40
  • 1
Monoclonal

Conjugate

  • 64
  • 12
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This Complement Factor H antibody is un-conjugated

Application

  • 78
  • 49
  • 32
  • 32
  • 26
  • 17
  • 13
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Clone

6F11
  • Cross-Reactivity

    Human

    Purification

    Purified by Protein A.

    Immunogen

    Full length protein

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    FCM 1:20-100
    IF(ICC) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    Complement Factor H (CFH)

    Alternative Name

    Factor H

    Background

    Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

    Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

    Gene ID

    3075

    UniProt

    P08603

    Pathways

    Complement System, Cellular Response to Molecule of Bacterial Origin
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