Frataxin antibody

Catalog No. ABIN6943478

This anti-Frataxin antibody is a Rabbit Monoclonal antibody detecting Frataxin in WB. Suitable for Human.

Quick Overview for Frataxin antibody (ABIN6943478)

Target: Frataxin (FXN)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Frataxin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2G1

Product Details anti-Frataxin Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Full length recombinant human Frataxin protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Frataxin

Target: Frataxin (FXN)

Alternative Name: FRATAXIN

Background:

Synonyms: Frataxin, mitochondrial, FXN, Friedreich ataxia protein, FRDA, X25

Background: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+, the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization, however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.

Gene ID: 2395

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size