Frataxin antibody (N-Term)

Catalog No. ABIN1881356

There are 4+ publications for this product available. The Rabbit Polyclonal anti-Frataxin antibody is suitable to detect Frataxin in samples from Human. It has been validated for WB.

Quick Overview for Frataxin antibody (N-Term) (ABIN1881356)

Target: Frataxin (FXN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Frataxin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41914

Product Details anti-Frataxin Antibody

Binding Specificity: AA 36-64, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human FXN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Frataxin antibody (ABIN1881356)

Tsai, Barondeau: "Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex." in: Biochemistry, Vol. 49, Issue 43, pp. 9132-9, (2010) (PubMed).

Thierbach, Drewes, Fusser, Voigt, Kuhlow, Blume, Schulz, Reiche, Glatt, Epe, Steinberg, Ristow: "The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals." in: The Biochemical journal, Vol. 432, Issue 1, pp. 165-72, (2010) (PubMed).

Mariño, Zaldivar, Mesa, Mederos, Rodríguez, Gotay, Labrada, Ochoa, Macleod, Pérez: "Low predisposition to instability of the Friedreich ataxia gene in Cuban population." in: Clinical genetics, Vol. 77, Issue 6, pp. 598-600, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Target Details for Frataxin

Target: Frataxin (FXN)

Alternative Name: FXN

Background: This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Molecular Weight: 23135

NCBI Accession: NP_000135, NP_001155178, NP_852090

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size