MADD antibody (AA 851-950) (HRP)

Catalog No. ABIN6943984

The Rabbit Polyclonal anti-MADD antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect MADD in samples from Mouse.

Quick Overview for MADD antibody (AA 851-950) (HRP) (ABIN6943984)

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MADD antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MADD Antibody (HRP)

Binding Specificity: AA 851-950

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DENN

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MADD

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Alternative Name: MADD

Background:

Synonyms: Differentially expressed in normal and neoplastic cells, FLJ35600, IG20, Insulinoma glucagonoma clone 20, KIAA0358, MADD, MADD_HUMAN, MAP kinase-activating death domain protein, Rab3 GDP/GTP exchange factor, RAB3GEP, DENN

Background: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene ID: 8567

UniProt: Q8WXG6

Pathways: Caspase Cascade in Apoptosis