NFKBIE antibody

Catalog No. ABIN6944283

This Rabbit Monoclonal antibody specifically detects NFKBIE in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for NFKBIE antibody (ABIN6944283)

Target: NFKBIE (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, epsilon (NFKBIE))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NFKBIE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7A4

Product Details anti-NFKBIE Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Full length protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for NFKBIE

Target: NFKBIE (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, epsilon (NFKBIE))

Alternative Name: NFKBIE

Background:

Synonyms: NF-kappa-B inhibitor epsilon, I-kappa-B-epsilon, NF-kappa-BIE, IkB-E, IkB-epsilon, IKB epsilon, IkappaBepsilon, NFKBIE, NFKB inhibitor epsilon

Background: The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene ID: 4794

UniProt: O00221

Pathways: NF-kappaB Signaling, Maintenance of Protein Location