NMDAR2A antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a) (pSer1232) (Biotin)

Details for Product anti-GRIN2A Antibody No. ABIN6944295
Antigen
  • NMDAR2A
  • nr2a
  • GRIN2A
  • EPND
  • GluN2A
  • NR2A
  • glutamate ionotropic receptor NMDA type subunit 2A
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog
  • glutamate receptor ionotropic, NMDA 2A
  • glutamate receptor, ionotropic, NMDA2A (epsilon 1)
  • GRIN2A
  • grin2a.L
  • LOC100438553
  • Grin2a
Epitope
pSer1232
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28
20
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15
9
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3
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3
3
3
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2
1
1
1
1
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1
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1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
248
201
191
8
4
3
2
2
1
1
1
Host
Rabbit
211
96
1
Clonality
Polyclonal
Conjugate
This NMDAR2A antibody is conjugated to Biotin
19
16
13
8
8
8
6
6
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6
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4
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4
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Options
Immunogen KLH conjugated Synthesised phosphopeptide derived from human NMDAR2A around the phosphorylation site of Ser1232
Isotype IgG
Specificity This phosphorylated site is homologous to that of Ser1232 in Mouse and Rat.
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others NMDAR2A products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NMDAR2A (GRIN2A Antibody Abstract)
Background

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

Subcellular location: Cell membrane


Synonyms: NMDAR2A (phospho S1232), p-NMDAR2A (phospho S1232), GRIN2B, Glutamate [NMDA] receptor subunit epsilon 1, Glutamate [NMDA] receptor subunit epsilon 2, Glutamate [NMDA] receptor subunit epsilon-1, Glutamate [NMDA] receptor subunit epsilon-2, GRIN2A, hNR2A, hNR3, N methyl D aspartate receptor subtype 2A, N methyl D aspartate receptor subtype 2B, N-methyl D-aspartate receptor subtype 2A, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDAR2A, NMDAR2B, NMDE2_HUMAN, NR2A, NR2B, NR3.
Gene ID 2903
UniProt Q12879
Pathways Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes IHC-P(1:200-400)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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