PDI antibody (Prolyl 4-Hydroxylase, beta Polypeptide)

Details for Product anti-P4HB Antibody No. ABIN6944472
Antigen
  • DSI
  • ERBA2L
  • GIT
  • P4Hbeta
  • PDI
  • PDIA1
  • PHDB
  • PO4DB
  • PO4HB
  • PROHB
  • ERp59
  • Pdia1
  • Thbp
  • PDIR
  • p55
  • p58
  • prolyl 4-hydroxylase subunit beta
  • prolyl 4-hydroxylase, beta polypeptide
  • prolyl 4-hydroxylase subunit beta L homeolog
  • protein disulfide-isomerase
  • P4HB
  • P4hb
  • p4hb.L
  • LOC8281065
Reactivity
Human, Mouse (Murine), Rat (Rattus)
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7
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1
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1
Host
Rabbit
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65
4
Clonality (Clone)
Monoclonal ()
Conjugate
This PDI antibody is un-conjugated
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21
15
5
4
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4
4
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2
1
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Application
Flow Cytometry (FACS), Western Blotting (WB)
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Options
Immunogen Human PD1 between 1 to 200 amino acids
Clone 6C9
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PDI products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PDI (P4HB Antibody Abstract)
Background

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9, the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).


Synonyms: Protein disulfide-isomerase A2, PDIp, Pdia2
Gene ID 5034
UniProt P07237
Pathways Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
Application Notes WB(1:300-1000), FCM(1:20-100)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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