PPP2R4 antibody (Protein Phosphatase 2A Activator, Regulatory Subunit 4) (pTyr307)

Details for Product anti-PPP2R4 Antibody No. ABIN6944643
Antigen
  • PP2A
  • PR53
  • PTPA
  • 2610042B21Rik
  • C77440
  • N28142
  • PTPRA
  • Ppp2r4
  • fc23d07
  • ppp2r4
  • wu:fc23d07
  • zgc:92766
  • pp2a
  • ppp2r4.L
  • pr53
  • ptpa
  • protein phosphatase 2 phosphatase activator
  • protein phosphatase 2 protein activator
  • protein phosphatase 2 phosphatase activator L homeolog
  • PTPA
  • Ptpa
  • ptpa
  • ptpa.L
Epitope
pTyr307
12
9
6
4
4
3
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
88
45
41
4
2
2
2
2
2
2
1
1
Host
Rabbit
77
15
2
Clonality (Clone)
Monoclonal ()
Conjugate
This PPP2R4 antibody is un-conjugated
5
4
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (IHC), Western Blotting (WB)
71
33
29
13
7
6
5
4
4
2
2
1
1
1
Options
Immunogen Synthetic phospho-peptide around human PP2A Tyr307
Clone 29A1
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others PPP2R4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name PP2A (PPP2R4 Antibody Abstract)
Background

Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by α and β isoforms. Additional regulatory subunits belong to four different families of unrelated proteins. Both the B (or PR55) and B' regulatory protein families contain α, β, γ and δ isoforms, with the B' family also including an ε protein. B'' family proteins include PR72, PR130, PR59 and PR48 isoforms, while striatin (PR110) and SG2NA (PR93) are both members of the B''' regulatory protein family. These B subunits competitively bind to a shared binding site on the core A subunit. This variable array of holoenzyme components, particularly regulatory B subunits, allows PP2A to act in a diverse set of functions. PP2A function is regulated by expression, localization, holoenzyme composition and post-translational modification. Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity. Reversible methylation on the carboxyl group of Leu309 of PP2A has been observed. Methylation alters the conformation of PP2A, as well as its localization and association with B regulatory subunits.


Synonyms: PP2A A, PP2A alpha, PP2A B, PP2A beta antibody, PP2A-alpha
UniProt P62714, P67775
Pathways PI3K-Akt Signaling, M Phase, Hepatitis C, Toll-Like Receptors Cascades
Application Notes WB(1:300-1000), IF(ICC)(1:50-200), IHC()
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months
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