PEN2 antibody

Catalog No. ABIN6944688

This Rabbit Monoclonal antibody specifically detects PEN2 in WB, IF (cc), IF (p), IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PEN2 antibody (ABIN6944688)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 1D8

Product Details anti-PEN2 Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PSENEN

Background:

Synonyms: Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PSENEN, PEN2, presenilin enhancer gamma-secretase subunit, MDS033

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Gene ID: 55851

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway