TBP antibody

Catalog No. ABIN6945137

This anti-TBP antibody is a Mouse Monoclonal antibody detecting TBP in WB and ChIP-seq. Suitable for Human.

Quick Overview for TBP antibody (ABIN6945137)

Target: TBP (TATA Box Binding Protein (TBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBP antibody is un-conjugated

Application: Western Blotting (WB), ChIP DNA-Sequencing (ChIP-seq)

Clone: 2C9

Product Details anti-TBP Antibody

Cross-Reactivity: Human

Purification: Monoclonal antibody in PBS containing 0.05% azide, purified by ammonium sulphate precipitation followed by dialysis

Immunogen: Monoclonal antibody raised in mouse against the amino-terminal domain of human TBP (TATA box binding protein).

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
ChIP-seq()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 8 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TBP

Target: TBP (TATA Box Binding Protein (TBP))

Alternative Name: TBP

Background:

Synonyms: GTF2D, GTF2D1, SCA17, TF2D, TFIID

Background: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

Gene ID: 6908

UniProt: P20226

Pathways: WNT Signaling