IL-4 antibody

Catalog No. ABIN6964013

This Rat Monoclonal antibody specifically detects IL-4 in Neut. It exhibits reactivity toward Mouse and has been mentioned in 3+ publications.

Quick Overview for IL-4 antibody (ABIN6964013)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-4 antibody is un-conjugated

Application: Neutralization (Neut)

Clone: 11B11

Product Details anti-IL-4 Antibody

Specificity: Native and recombinant mouse IL-4

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Immunogen: Recombinant mouse IL-4

Isotype: IgG1

Application Details

Application Notes: Neutralization of mouse IL-4 bioactivity. It is recommended to establish the optimal antibody concentration for the assay system used. The antibody is also suitable for immunoassays.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: supplied at 1 mg/mL in PBS free of preservatives

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-IL-4 antibody (ABIN6964013)

Cavassani, Tristao, Oliveira, Rocha, Vancim, Moreira, Campanelli, Panagio, Milanezi, Martinez, Rossi, Silva: "Cell-free antigens from Paracoccidioides brasiliensis drive IL-4 production and increase the severity of paracoccidioidomycosis." in: PLoS ONE, Vol. 6, Issue 6, pp. e21423, (2011) (PubMed).

Costa, Carregaro, Lima-Júnior, Silva, Milanezi, Cardoso, Giudice, de Jesus, Carvalho, Almeida, Silva: "BALB/c mice infected with antimony treatment refractory isolate of Leishmania braziliensis present severe lesions due to IL-4 production." in: PLoS neglected tropical diseases, Vol. 5, Issue 3, pp. e965, (2011) (PubMed).

Iizuka, Ikarashi, Yoshida, Heike, Takeda, Quinn, Wakasugi, Kitagawa, Takaue: "Interleukin (IL)-4 promotes T helper type 2-biased natural killer T (NKT) cell expansion, which is regulated by NKT cell-derived interferon-gamma and IL-4." in: Immunology, Vol. 123, Issue 1, pp. 100-7, (2008) (PubMed).

Target Details for IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: IL4

Gene ID: 16189

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation