beta Catenin antibody (N-Term)
Quick Overview for beta Catenin antibody (N-Term) (ABIN6971443)
Target
See all beta Catenin (CATNB) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- N-Term
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Characteristics
- beta-Catenin is a key downstream component of the canonical Wnt signaling pathway, plays an important role in the regulation of cell adhesion and embryonic development. In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of beta-Catenin via BTRC and subsequent degradation by the proteasome. In the presence of Wnt ligand, beta-Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. beta-Catenin antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.
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Purification
- Affinity Purified
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Immunogen
- This antibody was raised against a peptide within the N-terminal region of human beta-Catenin.
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Isotype
- IgG
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anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibody
CATNB Reactivity: Human, Mouse, Rat WB, FACS, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 661-781) antibodyCATNB Reactivity: Human, Mouse, Rat, Pig, Zebrafish (Danio rerio) WB, FACS, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Pig, Rabbit, Sheep, Monkey, Hamster, Avian, Cat, Donkey, Goat, Guinea Pig, Horse WB, IF Host: Goat Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB Reactivity: Human, Zebrafish (Danio rerio) WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37), (pThr41) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Hamster WB, IP, ICC, ICFC Host: Mouse Monoclonal EM-22 unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC Host: Mouse Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) (AA 764-781) antibodyCATNB Reactivity: Human, Mouse, Rat WB, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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Alternative Name
- beta-Catenin
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Molecular Weight
- 90 kDa
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NCBI Accession
- NP_001895
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Pathways
- Peptide Hormone Metabolism
Target
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