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- Target See all SETD7 Antibodies
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SETD7 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Characteristics
- SETD7 / SET7 (SET Domain Containing (Lysine Methyltransferase) 7) is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. SETD7 / SET7 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
- Purification
- Affinity Purified
- Immunogen
- This antibody was raised against a peptide within human SETD7 / SET7.
- Isotype
- IgG
- Top Product
- Discover our top product SETD7 Primary Antibody
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anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 107-366) antibody
SETD7 Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 1B3B8 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 107-366) antibodySETD7 Reactivity: Human WB, ELISA, IHC Host: Mouse Monoclonal 3D6G11 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 257-366) antibodySETD7 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 5B4 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 159-189) antibodySETD7 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB2763 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 257-366) antibodySETD7 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) antibodySETD7 Reactivity: Human, Mouse WB, FACS Host: Mouse Monoclonal 2E3 unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 1-366) antibodySETD7 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (AA 1-218) antibodySETD7 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (Internal Region) antibodySETD7 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-SET Domain Containing (Lysine Methyltransferase) 7 (SETD7) (C-Term) antibodySETD7 Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow, Zebrafish (Danio rerio), Monkey, Bat WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- Target
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
- Alternative Name
- SETD7 / SET7 (SETD7 Products)
- Molecular Weight
- 60 kDa
- NCBI Accession
- NP_085151
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