HTRA2 antibody (AA 231-330) (AbBy Fluor® 488)

Catalog No. ABIN6977839

This Rabbit Polyclonal antibody specifically detects HTRA2 in WB, IF (p) and IF (cc). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HTRA2 antibody (AA 231-330) (AbBy Fluor® 488) (ABIN6977839)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTRA2 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-HTRA2 Antibody (AbBy Fluor® 488)

Binding Specificity: AA 231-330

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HTRA2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2

Background:

Synonyms: Serine protease HTRA2, mitochondrial, HTRA2, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25 Serine proteinase OMI, HTRA2, OMI, PRSS25

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Gene ID: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity