NOS2 antibody (AA 811-910) (Biotin)

Catalog No. ABIN6982930

This Rabbit Polyclonal antibody specifically detects NOS2 in IHC (p). It exhibits reactivity toward Rat.

Quick Overview for NOS2 antibody (AA 811-910) (Biotin) (ABIN6982930)

Target: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOS2 antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NOS2 Antibody (Biotin)

Binding Specificity: AA 811-910

Cross-Reactivity: Rat

Predicted Reactivity: Mouse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse iNOS

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for NOS2

Target: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Alternative Name: iNOS

Background:

Synonyms: i NOS, I-NOS, Nitric Oxide Synthase, Inducible, HEP NOS, Hepatocyte NOS, HEPNOS, Inducible nitric oxide synthase, Inducible NO synthase, Inducible NOS, INOS, Inosl, MAC NOS, Macrophage NOS, Nitric oxide synthase 2 inducible macrophage, Nitric oxide synthase 2A (inducible hepatocytes), Nitric oxide synthase inducible, NOS 2, NOS 2A, NOS, Nos II, NOS type II, Nos2, NOS2A, NOS2_HUMAN.

Background: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Gene ID: 18126

UniProt: P29477

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process