FLIP antibody (AA 1-100) (Biotin)

Catalog No. ABIN6983071

This Rabbit Polyclonal antibody specifically detects FLIP in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FLIP antibody (AA 1-100) (Biotin) (ABIN6983071)

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLIP antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FLIP Antibody (Biotin)

Binding Specificity: AA 1-100

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CFLIP

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FLIP

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Alternative Name: CFLIP

Background:

Synonyms: c FLIP, c FLIPL, c FLIPR, c FLIPS, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASH, CASP8 and FADD like apoptosis regulator, CASP8 and FADD-like apoptosis regulator subunit p12, CASP8AP1, Caspase homolog, Caspase like apoptosis regulatory protein, Caspase related inducer of apoptosis, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Casper, Cellular FLICE-like inhibitory protein, CFLA, Cflar, CFLAR_HUMAN, CLARP, FADD like anti apoptotic molecule, FADD-like antiapoptotic molecule 1, FLAME, FLAME-1, FLAME1, FLIP, I FLICE, I-FLICE, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, OTTHUMP00000163715, OTTHUMP00000206475, OTTHUMP00000206476, OTTHUMP00000206478, OTTHUMP00000206479, OTTHUMP00000206480, OTTHUMP00000206482, OTTHUMP00000207360, Usurpin, Usurpin beta.

Background: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene ID: 8837

UniProt: O15519

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development