kappa Light Chain antibody (AA 1-107) (Biotin)

Catalog No. ABIN6983160

This anti-kappa Light Chain antibody is a Rabbit Monoclonal antibody detecting kappa Light Chain in WB and IHC (p). Suitable for Human.

Quick Overview for kappa Light Chain antibody (AA 1-107) (Biotin) (ABIN6983160)

Target: kappa Light Chain

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This kappa Light Chain antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 9B1

Product Details anti-kappa Light Chain Antibody (Biotin)

Binding Specificity: AA 1-107

Purification: Purified by Protein A.

Immunogen: Full length native human IgG.

Isotype: IgG

Application Details

Application Notes: WB 1:300-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C

Expiry Date: 12 months

Target Details for kappa Light Chain

Target: kappa Light Chain

Background:

Immunoglobulins belong to a group of related glyco proteins which make up 20 % of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit, while, IgM is a pen tamer. IgA may also form polymers.
Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.

Subcellular location: Extracellular, Secreted

Synonyms: Kappa Light Chain, IGKC, HCAK 1, HCAK1, Ig kappa chain C region, IGKC, Immunoglobulin kappa constant, Immunoglobulin kappa constant region, Immunoglobulin kappa light chain, Kappa 1 immunoglobulin light chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809, Human Ig/L-Chain Kappa, IGKC_HUMAN.

Gene ID: 3514

UniProt: P01834