Calsequestrin antibody (AA 1-100) (Cy3)

Catalog No. ABIN6983708

The Rabbit Polyclonal anti-Calsequestrin antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect Calsequestrin in samples from Human.

Quick Overview for Calsequestrin antibody (AA 1-100) (Cy3) (ABIN6983708)

Target: Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calsequestrin antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Calsequestrin Antibody (Cy3)

Binding Specificity: AA 1-100

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calsequestrin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calsequestrin

Target: Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))

Alternative Name: Calsequestrin-1

Background:

Synonyms: CASQ, Calsequestrin 1, Calsequestrin 1 fast twitch skeletal muscle, Calsequestrin skeletal muscle isoform, CASQ 1, CASQ1, PDIB1, Skeletal muscle calsequestrin 1, Calmitine.

Background: The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.

Gene ID: 844

UniProt: P31415