STIM1 antibody (AA 601-685) (Cy3)

Catalog No. ABIN6983819

The Rabbit Polyclonal anti-STIM1 antibody has been validated for IF (p) and IF (cc). It is suitable to detect STIM1 in samples from Human and Rat.

Quick Overview for STIM1 antibody (AA 601-685) (Cy3) (ABIN6983819)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIM1 antibody is conjugated to Cy3

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-STIM1 Antibody (Cy3)

Binding Specificity: AA 601-685

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human STIM1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Alternative Name: STIM1

Background:

Synonyms: GOK, SIM, STIM 1, STIM1, STIM-1, Stim1 stromal interaction molecule 1, STIM1_HUMAN, STIM1L, Stromal interaction molecule 1.

Background: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

Gene ID: 6786

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling