FLIP antibody (AA 1-100) (Cy3)

Catalog No. ABIN6983974

This Rabbit Polyclonal antibody specifically detects FLIP in WB and IF (cc). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FLIP antibody (AA 1-100) (Cy3) (ABIN6983974)

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLIP antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-FLIP Antibody (Cy3)

Binding Specificity: AA 1-100

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CFLIP

Isotype: IgG

Application Details

Application Notes: IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FLIP

Target: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Alternative Name: CFLIP

Background:

Synonyms: c FLIP, c FLIPL, c FLIPR, c FLIPS, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASH, CASP8 and FADD like apoptosis regulator, CASP8 and FADD-like apoptosis regulator subunit p12, CASP8AP1, Caspase homolog, Caspase like apoptosis regulatory protein, Caspase related inducer of apoptosis, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Casper, Cellular FLICE-like inhibitory protein, CFLA, Cflar, CFLAR_HUMAN, CLARP, FADD like anti apoptotic molecule, FADD-like antiapoptotic molecule 1, FLAME, FLAME-1, FLAME1, FLIP, I FLICE, I-FLICE, Inhibitor of FLICE, MACH-related inducer of toxicity, MRIT, OTTHUMP00000163715, OTTHUMP00000206475, OTTHUMP00000206476, OTTHUMP00000206478, OTTHUMP00000206479, OTTHUMP00000206480, OTTHUMP00000206482, OTTHUMP00000207360, Usurpin, Usurpin beta.

Background: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene ID: 8837

UniProt: O15519

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development