HUS1 antibody (AA 51-150) (Cy5.5)

Catalog No. ABIN6985245

This anti-HUS1 antibody is a Rabbit Polyclonal antibody detecting HUS1 in IF (cc) and IF (p). Suitable for Rat.

Quick Overview for HUS1 antibody (AA 51-150) (Cy5.5) (ABIN6985245)

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HUS1 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HUS1 Antibody (Cy5.5)

Binding Specificity: AA 51-150

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HUS1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HUS1

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Alternative Name: HUS1

Background:

Synonyms: Checkpoint protein HUS1, hHUS1, HUS1 (S. pombe) checkpoint homolog, Hus1, HUS1 checkpoint homolog (S. pombe), HUS1 Checkpoint Protein, HUS1 protein, HUS1+ - like protein, HUS1_HUMAN, Hydroxyurea-sensitive 1, S. pombe, homolog of.

Background: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Gene ID: 3364

UniProt: O60921