Importin 8 antibody (AA 1-100) (FITC)

Catalog No. ABIN6987132

This anti-Importin 8 antibody is a Rabbit Polyclonal antibody detecting Importin 8 in IF (cc) and IF (p). Suitable for Rat.

Quick Overview for Importin 8 antibody (AA 1-100) (FITC) (ABIN6987132)

Target: Importin 8 (IPO8)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 8 antibody is conjugated to FITC

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Importin 8 Antibody (FITC)

Binding Specificity: AA 1-100

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Importin 8

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Importin 8

Target: Importin 8 (IPO8)

Alternative Name: Importin 8

Background:

Synonyms: FLJ26580, Imp 8, Imp8, Importin-8, Importin8, IPO 8, IPO8, IPO8_HUMAN, Ran binding protein 8, RAN BP8, Ran-binding protein 8, RANBP 8, RANBP8.

Background: Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19.

Gene ID: 10526

UniProt: O15397