TOP2B antibody (AA 1-100) (HRP)

Catalog No. ABIN6987565

This Rabbit Polyclonal antibody specifically detects TOP2B in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human and Rat.

Quick Overview for TOP2B antibody (AA 1-100) (HRP) (ABIN6987565)

Target: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOP2B antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TOP2B Antibody (HRP)

Binding Specificity: AA 1-100

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit,Chimpanzee

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Topoisomerase II beta

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TOP2B

Target: TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))

Alternative Name: Topoisomerase II beta

Background:

Synonyms: Antigen MLAA 44, beta isozyme, DNA topoisomerase 2 beta, DNA topoisomerase 2-beta, DNA topoisomerase II 180 kD, DNA topoisomerase II, DNA topoisomerase II beta, DNA topoisomerase II beta isozyme, Top 2, TOP 2B, TOP IIB, Top2 beta, TOP2B, TOP2B_HUMAN, Top2beta, TOPIIB, Topo II beta, Topoisomerase (DNA) II beta 180 kDa, Topoisomerase (DNA) II beta, Topoisomerase IIb, U937 associated antigen.

Background: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Gene ID: 7155

UniProt: Q02880