HMGB3 antibody (HRP)

Catalog No. ABIN6987988

This Rabbit Polyclonal antibody specifically detects HMGB3 in IHC (p). It exhibits reactivity toward Mouse and Rat.

Quick Overview for HMGB3 antibody (HRP) (ABIN6987988)

Target: HMGB3 (High Mobility Group Box 3 (HMGB3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGB3 antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HMGB3 Antibody (HRP)

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HMG4/HMGB3:1-100/200

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HMGB3

Target: HMGB3 (High Mobility Group Box 3 (HMGB3))

Alternative Name: HMG4/HMGB3

Background:

Synonyms: High mobility group (nonhistone chromosomal) protein 4, High mobility group box 3, High mobility group protein 2a, High mobility group protein 4, High mobility group protein B3, High mobility group protein HMG4, HMG 4, HMG-2a, HMG-4, HMG2A, HMGB 3, HMGB3, HMGB3_HUMAN, MGC90319, Non histone chromosomal protein, Nonhistone chromosomal protein HMG4.

Background: HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke et al., 1997 [PubMed 9370291], Nemeth et al., 2006 [PubMed 16945912]).[supplied by OMIM, Mar 2008] Function : Binds preferentially single-stranded DNA and unwinds double stranded DNA. Similarity : Belongs to the HMGB family. Contains 2 HMG box DNA-binding domains.

Gene ID: 3149

UniProt: O15347