MBP antibody (pThr232) (PE)

Catalog No. ABIN6988827

The PE-conjugated Rabbit Polyclonal anti-MBP antibody (ABIN6988827) specifically detects MBP in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MBP antibody (pThr232) (PE) (6988827)

Target: MBP

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBP antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-MBP Antibody (PE)

Binding Specificity: pThr232

Specificity: This antibody recognizes Thr229 in mice and Thr122 in rat

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MBP around the phosphorylation site of Thr232

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MBP

Target: MBP

Background:

Synonyms: Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

Background: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Gene ID: 4155

UniProt: P02686