CD34 antibody

Catalog No. ABIN6989467

This Rabbit Monoclonal antibody specifically detects CD34 in FACS and IHC (p). It exhibits reactivity toward Human, Rat, Mouse and Dog.

Quick Overview for CD34 antibody (ABIN6989467)

Target: CD34

Reactivity: Human, Rat, Mouse, Dog

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD34 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7A1

Product Details anti-CD34 Antibody

Cross-Reactivity: Dog, Human, Mouse, Rat

Purification: Purified by Protein G.

Immunogen: Recombinant human CD34

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CD34

Target: CD34

Alternative Name: CD34

Background:

Synonyms: CD34 antigen, CD34 Molecule, Cluster designation 34, Hematopoietic progenitor cell antigen CD34, HPCA1, CD34_HUMAN.

Background: The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Gene ID: 947

UniProt: P28906