GFRA1 antibody (AA 360-410)

Catalog No. ABIN6990250

This Rabbit Polyclonal antibody specifically detects GFRA1 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GFRA1 antibody (AA 360-410) (ABIN6990250)

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GFRA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GFRA1 Antibody

Binding Specificity: AA 360-410

Specificity: GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

Purification: GFR alpha 1 Antibody is Antibody is DEAE purified.

Immunogen: GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. The immunogen is located within amino acids 360 - 410 of GFR alpha 1.

Isotype: IgG

Application Details

Application Notes: GFR alpha 1 antibody can be used for detection of GFR alpha 1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GFR alpha 1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GFR alpha 1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Alternative Name: GFR alpha 1

Background: GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα,-1 recently. GFRα,-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα, and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

Molecular Weight: 51 kDa

Gene ID: 2674

UniProt: P56159