BCAP31 antibody (AA 130-180)

Catalog No. ABIN6990318

This anti-BCAP31 antibody is a Rabbit Polyclonal antibody detecting BCAP31 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for BCAP31 antibody (AA 130-180) (ABIN6990318)

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCAP31 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BCAP31 Antibody

Binding Specificity: AA 130-180

Purification: BAP31 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-BAP31 antibody was raised against a peptide corresponding to 16 amino acids near the center of human BAP31. The immunogen is located within amino acids 130 - 180 of BAP31.

Isotype: IgG

Application Details

Application Notes: WB: 0.5-2 μ,g/mL, IHC: 10 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: BAP31 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: BAP31 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for BCAP31

Target: BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))

Alternative Name: BAP31

Background: BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. Bap31 may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopically, is also a potent inducer cell death.

Molecular Weight: Predicted: 28 or 34kD

Observed: 28 kD kDa

Gene ID: 10134

NCBI Accession: NP_005736

UniProt: P51572

Pathways: Positive Regulation of Endopeptidase Activity