FAIM antibody (C-Term)

Catalog No. ABIN6990345

This anti-FAIM antibody is a Rabbit Polyclonal antibody detecting FAIM in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for FAIM antibody (C-Term) (ABIN6990345)

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FAIM Antibody

Binding Specificity: C-Term

Purification: FAIM Antibody is affinity chromatography purified via peptide column.

Immunogen: FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM. The immunogen is located within the last 50 amino acids of FAIM.

Isotype: IgG

Application Details

Application Notes: FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FAIM Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FAIM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for FAIM

Target: FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))

Alternative Name: FAIM

Background: FAIM Antibody: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κ,B and the Ras-ERK pathway.

Gene ID: 55179

NCBI Accession: NP_060617

UniProt: Q9NVQ4