DC-SIGN/CD209 antibody (AA 250-300)

Catalog No. ABIN6990356

The Rabbit Polyclonal anti-DC-SIGN/CD209 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect DC-SIGN/CD209 in samples from Human.

Quick Overview for DC-SIGN/CD209 antibody (AA 250-300) (ABIN6990356)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DC-SIGN/CD209 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DC-SIGN/CD209 Antibody

Binding Specificity: AA 250-300

Purification: DC-SIGN Antibody is affinity chromatography purified via peptide column.

Immunogen: DC-SIGN antibody was raised against a synthetic peptide corresponding to 17 amino acids near the center of human DC-SIGN. The immunogen is located within amino acids 250 - 300 of DC-SIGN.

Isotype: IgG

Application Details

Application Notes: DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DC-SIGN Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DC-SIGN antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: DC-SIGN

Background: DC-SIGN Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Molecular Weight: Predicted: 44 kDa

Observed: 47 kDa

Gene ID: 30835

UniProt: Q9NNX6