AVEN antibody (C-Term)

Catalog No. ABIN6990365

The Rabbit Polyclonal anti-AVEN antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect AVEN in samples from Human, Mouse and Rat.

Quick Overview for AVEN antibody (C-Term) (ABIN6990365)

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVEN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AVEN Antibody

Binding Specificity: C-Term

Purification: Aven Antibody is affinity chromatography purified via peptide column.

Immunogen: Aven antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Aven. The immunogen is located within the last 50 amino acids of Aven.

Isotype: IgG

Application Details

Application Notes: Aven antibody can be used for detection of Aven by Western blot at 1 μ,g/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Aven Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Aven antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Alternative Name: Aven

Background: Aven Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

Gene ID: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1