IRF8 antibody (C-Term)

Catalog No. ABIN6990493

This Rabbit Polyclonal antibody specifically detects IRF8 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for IRF8 antibody (C-Term) (ABIN6990493)

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-IRF8 Antibody

Binding Specificity: C-Term

Purification: IRF8 Antibody is affinity chromatography purified via peptide column.

Immunogen: IRF8 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8. The immunogen is located within the last 50 amino acids of IRF8.

Isotype: IgG

Application Details

Application Notes: IRF8 antibody can be used for detection of IRF8 by Western blot at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IRF8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IRF8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Alternative Name: IRF8

Background: IRF8 Antibody: Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Unlike IRF3, IRF8 appears to act as a negative regulator of IFN-induced genes in most cases, but IRF8 mediates activation of NF-κ,B by the toll-like receptor 9 (TLR9) after stimulation by unmethylated CpG DNA in dendritic cells. Finally, it has been shown that IRF8 decreases bcl-2 expression and thus may play a role in chronic myelogenous leukemia.

Gene ID: 3394

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin