ADIPOQ antibody (N-Term)

Catalog No. ABIN6990546

This anti-ADIPOQ antibody is a Rabbit Polyclonal antibody detecting ADIPOQ in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for ADIPOQ antibody (N-Term) (ABIN6990546)

Target: ADIPOQ (Adiponectin (ADIPOQ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADIPOQ antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ADIPOQ Antibody

Binding Specificity: AA 40-90, N-Term

Purification: Adiponectin Antibody is affinity chromatography purified via peptide column.

Immunogen: Adiponectin antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human adiponectin. The immunogen is located within amino acids 40 - 90 of Adiponectin.

Isotype: IgG

Application Details

Application Notes: Adiponectin antibody can be used for the detection of adiponectin by Western blot at 1 to 4 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 1 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Adiponectin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Adiponectin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for ADIPOQ

Target: ADIPOQ (Adiponectin (ADIPOQ))

Alternative Name: Adiponectin

Background: Adiponectin Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases.

Gene ID: 9370

NCBI Accession: NP_004788

UniProt: Q15848