C1QTNF2 antibody

Catalog No. ABIN6990599

The Rabbit Polyclonal anti-C1QTNF2 antibody has been validated for WB, ELISA, ICC and IF. It is suitable to detect C1QTNF2 in samples from Human, Mouse and Rat.

Quick Overview for C1QTNF2 antibody (ABIN6990599)

Target: C1QTNF2 (C1q and Tumor Necrosis Factor Related Protein 2 (C1QTNF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1QTNF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-C1QTNF2 Antibody

Specificity: These proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.

Purification: CTRP2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CTRP2 antibody was raised against recombinant human CTRP2.

Isotype: IgG

Application Details

Application Notes: CTRP2 antibody can be used for the detection of CTRP2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CTRP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CTRP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for C1QTNF2

Target: C1QTNF2 (C1q and Tumor Necrosis Factor Related Protein 2 (C1QTNF2))

Alternative Name: CTRP2

Background: CTRP2 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation.

Gene ID: 114898

NCBI Accession: NP_114114

UniProt: Q9BXJ5