IL23 antibody (C-Term)

Catalog No. ABIN6990631

This Rabbit Polyclonal antibody specifically detects IL23 in WB, ELISA, IHC (p), ICC and IF. It exhibits reactivity toward Human.

Quick Overview for IL23 antibody (C-Term) (ABIN6990631)

Target: IL23 (Interleukin 23 (IL23))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL23 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-IL23 Antibody

Binding Specificity: C-Term

Purification: IL-23 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-IL-23 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of mature human IL-23. The immunogen is located the last 50 amino acids of IL-23.

Isotype: IgG

Application Details

Application Notes: WB: 1-4 μ,g/mL, ICC: 10 μ,g/mL, IF: 20 μ,g/mL, IHC: 5 μ,g/mL.

Antibody validated: Western Blot, Immunocytochemistry, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-23 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-23 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for IL23

Target: IL23 (Interleukin 23 (IL23))

Alternative Name: IL-23

Background: IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α, from activated T cells, and can stimulate macrophages to produce TNF-α, and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

Molecular Weight: Predicted: 21kD

Observed: 22 kD kDa

Gene ID: 51561

UniProt: Q9NPF7