Clusterin antibody (Isoform 1)

Catalog No. ABIN6990650

The Rabbit Polyclonal anti-Clusterin antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect Clusterin in samples from Human and Mouse.

Quick Overview for Clusterin antibody (Isoform 1) (ABIN6990650)

Target: Clusterin (CLU)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Clusterin Antibody

Binding Specificity: Isoform 1

Purification: Clusterin Antibody is affinity chromatography purified via peptide column.

Immunogen: Clusterin antibody was raised recombinant human Clusterin isoform 1.

Isotype: IgG

Application Details

Application Notes: Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Clusterin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Clusterin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: Clusterin

Background: Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.

Gene ID: 1191

NCBI Accession: NP_001822

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling