PEN2 antibody (N-Term)

Catalog No. ABIN6990690

This anti-PEN2 antibody is a Rabbit Polyclonal antibody detecting PEN2 in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for PEN2 antibody (N-Term) (ABIN6990690)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PEN2 Antibody

Binding Specificity: N-Term

Purification: PEN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PEN2. The immunogen is located within the first 50 amino acids of PEN2.

Isotype: IgG

Application Details

Application Notes: PEN2 antibody can be used for detection of PEN2 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: PEN2

Background: PEN2 Antibody: PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

Gene ID: 55851

NCBI Accession: NP_758844

UniProt: Q9NZ42

Pathways: Notch Signaling, Neurotrophin Signaling Pathway